Thursday 22 October 2020
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medicalxpress - 7 days ago

Pancreatic cancer: Subtypes with different aggressiveness discovered

Tumors of the pancreas are particularly feared. They are usually discovered late and mortality is high. Until now, no targeted and personalized therapies exist. Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) have now succeeded for the first time in defining two differently aggressive molecular subtypes of pancreatic carcinoma. This provides new insights into the origin of the tumors. In the more aggressive group of tumors, a phenomenon known as viral mimicry leads to a cancer-promoting inflammatory reaction. This could possibly be the starting point for the development of a targeted, subtype-oriented therapy. The results have now been published in the journal Cancer Discovery.


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